Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases†
Thomas Regnier,Shigenobu Nishiguchi,Magne O. Sydnes,Daisuke Hashimoto,Junya Hasegawa,Takahiro Katoh,Tetsuya Kajimoto,Masataka Shiozuka,Ryoichi Matsuda,Manabu Node,Yoshiaki Kiso
Abstract
Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps.
