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Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives†
Cheng Cheng,Ying-Xian Li,Xue-Min Jia,Ji-Quan Zhang,Yong-Long Zhao,Wei Feng
RSC Advances Pub Date : 11/25/2020 00:00:00 , DOI:10.1039/D0RA07806A
Abstract

A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level.

Graphical abstract: Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives
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