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Enantioselective palladium-catalyzed arylation of N-tosylarylimines with arylboronic acids using a chiral 2,2′-bipyridine ligand†
Xiang Gao,Bo Wu,Zhong Yan,Yong-Gui Zhou
Organic & Biomolecular Chemistry Pub Date : 11/24/2015 00:00:00 , DOI:10.1039/C5OB02330K
Abstract

With the aid of an axially chiral 2,2′-bipyridine ligand, we have successfully developed a palladium-catalyzed method for the enantioselective arylation of N-tosylarylimines, furnishing the chiral diarylmethamines with high yields and enantioselectivities under very mild conditions. An exogenous base was avoided and imine hydrolysis was inhibited in this transformation.

Graphical abstract: Enantioselective palladium-catalyzed arylation of N-tosylarylimines with arylboronic acids using a chiral 2,2′-bipyridine ligand
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