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Efficient metal-free hydrosilylation of tertiary, secondary and primary amides to amines†
Enguerrand Blondiaux,Thibault Cantat
Chemical Communications Pub Date : 06/27/2014 00:00:00 , DOI:10.1039/C4CC02894E
Abstract

Hydrosilylation of secondary and tertiary amides to amines is described using catalytic amounts of B(C6F5)3. The organic catalyst enables the reduction of amides with cost-efficient, non-toxic and air stable PMHS and TMDS hydrosilanes. The methodology was successfully extended to the more challenging reduction of primary amides.

Graphical abstract: Efficient metal-free hydrosilylation of tertiary, secondary and primary amides to amines
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