Easy access to enamides: a mild nickel-catalysed alkene isomerization of allylamides†
Lu Wang,Chao Liu,Ruopeng Bai,Yani Pan
Chemical Communications Pub Date : 07/01/2013 00:00:00 , DOI:10.1039/C3CC43875A
Abstract

The first Ni-catalysed alkene isomerization of allylamides for the synthesis of enamides was demonstrated. Various substituted N-allylamides were found to be suitable substrates for this isomerization. Isotopic labelling experiments showed that it is an intramolecular hydrogen transfer process.

Graphical abstract: Easy access to enamides: a mild nickel-catalysed alkene isomerization of allylamides