Spinel-type Co₃O₄ has been reported to be the only transition metal oxide to date, which exhibits excellent catalytic activity for low temperature CO oxidation. But unfortunately, it is quickly deactivated by moisture. Here we report a Fe-doped Co₃O₄ spinel catalyst which demonstrates high activity and excellent moisture resistance for low temperature CO oxidation, especially at a low CO concentration of around 100 ppm which mimics the situations in automobile road tunnels and indoor parks.