Exo-Cyclopamine—a stable and potent inhibitor of hedgehog-signaling†
Philipp Heretsch,Anita Büttner,Lito Tzagkaroulaki,Stefan Zahn,Barbara Kirchner,Athanassios Giannis
Chemical Communications Pub Date : 05/17/2011 00:00:00 , DOI:10.1039/C1CC11782C
Abstract
The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.
