Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA†,10.1039/B823147H

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA†

Daniel Oves-Costales,Lijiang Song,Gregory L. Challis

Chemical Communications Pub Date : 02/16/2009 00:00:00 , DOI:10.1039/B823147H

Abstract

AsbA catalyses the highly enantioselective desymmetrisation of citric acidvia ATP-dependent condensation with spermidine, as well as the condensation of citric acid with several spermidine analogues and the condensation of the citric acid analogue tricarballylic acid with spermidine, suggesting that it may be a useful biocatalyst for asymmetric synthesis.