Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives†‡
Hai Yu,Kam Lau,Yanhong Li,Saddam Muthana,Junru Wang,Xi Chen
Chemical Communications Pub Date : 07/01/2011 00:00:00 , DOI:10.1039/C1CC12732B
Abstract
An N-terminal and C-terminal truncated recombinant α2–6-sialyltransferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15–501)-His6, was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.
