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A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes†
Paul H. Schlesinger,Riccardo Ferdani,Robert Pajewski,Jolanta Pajewska,George W. Gokel
Chemical Communications Pub Date : 03/19/2002 00:00:00 , DOI:10.1039/B200126H
Abstract

The heptapeptide sequence Gly-Gly-Gly-Pro-Gly-Gly-Gly, when anchored to diglycolic acid derived (C18H37)2NCOCH2OCH2COOH, forms chloride-selective ion channels in phospholipid liposomes but the related heptapeptide Gly-Gly-Gly-Leu-Gly-Gly-Gly, and tripeptide Gly-Gly-Gly do not.

Graphical abstract: A hydrocarbon anchored peptide that forms a chloride-selective channel in liposomes
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