Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes†
Xiaoyan Luo,Zhiqiang Zhou,Xin Li,Xinmiao Liang,Jinxing Ye
RSC Advances Pub Date : 08/25/2011 00:00:00 , DOI:10.1039/C1RA00269D
Abstract

The enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes with diaryl phosphine oxides is explored for the first time using (S)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine as a catalyst. It afforded 1,4-addition adducts in good to excellent yields with up to 99% ee.

Graphical abstract: Enantioselective organocatalytic phospha-Michael reaction of α,β-unsaturated aldehydes