Enantioselective syntheses of indanes: from organocatalysis to C–H functionalization†
Cyril Borie,Lutz Ackermann,Malek Nechab
Chemical Society Reviews Pub Date : 01/05/2016 00:00:00 , DOI:10.1039/C5CS00622H
Abstract

The indanyl core is ubiquitous in a large variety of drugs and natural products. Importantly, the ever-increasing demand for chiral catalysts bearing this scaffold calls for state of the art methods allowing for a step-economical enantioselective access to this structural motif. We herein summarize the asymmetric syntheses of indanes with a particular focus on asymmetric catalysis, covering the literature of the last decade until July 2015.

Graphical abstract: Enantioselective syntheses of indanes: from organocatalysis to C–H functionalization