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Direct N-cyclopropylation of secondary acyclic amides promoted by copper†
Emilie Racine,Florian Monnier,Jean-Pierre Vors,Marc Taillefer
Chemical Communications Pub Date : 07/17/2013 00:00:00 , DOI:10.1039/C3CC42575D
Abstract

The N-cyclopropylation of aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, has been accomplished using a simple and cheap copper system. The corresponding tertiary acyclic amides, which constitute a wide family of biologically active compounds, have been obtained in good to excellent yields.

Graphical abstract: Direct N-cyclopropylation of secondary acyclic amides promoted by copper
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