Enantioselective synthesis of highly functionalized octahydro-6-oxo-1-phenylnaphthalene-2-carbaldehydes via organocatalytic domino reactions†‡
Bor-Cherng Hong,Roshan Y. Nimje,Ju-Hsiou Liao
Organic & Biomolecular Chemistry Pub Date : 06/11/2009 00:00:00 , DOI:10.1039/B906205J
Abstract

Organocatalytic double Michael reaction and the subsequent aldol condensation of (E)-7-oxooct-5-enal and 3-arylpropenal (e.g., cinnamaldehyde) provided octahydro-6-oxo-1-phenylnaphthalene-2-carbaldehyde in high diastereoselectivity and high enantioselectivity (>99% ee). Structures of the adducts 5a and 5j were confirmed unambiguously by X-ray analysis.

Graphical abstract: Enantioselective synthesis of highly functionalized octahydro-6-oxo-1-phenylnaphthalene-2-carbaldehydes via organocatalytic domino reactions