Ene reactions between two alkynes? Doors open to thermally induced cycloisomerization of macrocyclic triynes and enediynes†
Iván González,Anna Pla-Quintana,Anna Roglans,Teodor Parella,Jordi Farjas,Pere Roura,Vega Lloveras,José Vidal-Gancedo
Abstract
A domino process is described combining an ene reaction between two alkynes and a Diels–Alder cycloaddition of the vinylallene formed. The process accounts for the thermally induced cycloisomerization of macrocyclic triynes and enediynes to give fused tetracycles in a stereoselective manner.
