The main objective of this study is to investigate the effect of process extraction variables (extraction time, volume of solvent, weight of sample) on the production of essential oil from ginger rhizome using Response Surface Methodology (RSM). A gas chromatography-mass spectrometry (GC-MS) method was employed to obtain the essential oil concentration in percentage (%) area. The RSM indicated that the weight of the sample had a major linear effect on the oil recovery while the extraction time had a major quadratic effect on the essential oil concentration in % area. The highest oil recovery and essential oil concentration in % area were 15.2% and 22.64%, respectively. The best operation conditions for the oil recovery were 4 hours of extraction time, 750 mL volume of methanol and 30 g weight of sample. The best operation conditions for the essential oil concentration in % area were 5 hours of extraction time, 500 mL volume of methanol and 30 g weight of sample.