Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats†,10.1039/C1CC11370D

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Fluorescent trimethyl-substituted naphthyridine as a ligand for C–C mismatch detection in CCG trinucleotide repeats†

Yusuke Sato,Atsuko Honjo,Daisuke Ishikawa,Seiichi Nishizawa,Norio Teramae

Chemical Communications Pub Date : 04/14/2011 00:00:00 , DOI:10.1039/C1CC11370D

Abstract

We report on the selective binding of 2-amino-5,6,7-trimethyl-1,8-naphthyridine (ATMND) to C–C mismatch present in the hairpin structures of (CCG)_n trinucleotide repeats that are associated with neurological diseases; this binding is accompanied by significant fluorescence quenching of ATMND.