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Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process†
Shiyong Peng,Lei Wang,Haibing Guo,Shaofa Sun,Jian Wang
Organic & Biomolecular Chemistry Pub Date : 02/07/2012 00:00:00 , DOI:10.1039/C2OB25075F
Abstract

3,4-Dihydrocoumarins, considered to be valuable building blocks, have attracted considerable attention due to their various biological activities. Herein, we have documented an efficient and convenient double decarboxylation process for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under mild reaction conditions (up to 98%).

Graphical abstract: Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process
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