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Facile protocol for the highly regioselective and stereodivergent synthesis of substituted bishomoallylic alcohols from esters
Martin Oestreich,Fernando Sempere-Culler
Chemical Communications Pub Date : 02/17/2004 00:00:00 , DOI:10.1039/B315758J
Abstract

Regio- and diastereoselective preparation of bishomoallylic alcohols was realized by a facile four-step protocol including α,α′-selective zinc-mediated bispropargylation of unactivated esters and stereoselective reduction of the resulting bishomopropargylic alcohols.

Graphical abstract: Facile protocol for the highly regioselective and stereodivergent synthesis of substituted bishomoallylic alcohols from esters
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