Recently, great effort has been made to improve the activity and stability, as well as increase the utilization efficiency of noble metal-based electrocatalysts. Herein, a dealloyed PtPd-based nanoparticle (PtPd-x/C, x = 0, 2, 4, 6, 8, 10), with a small amount of Fe inside, is obtained by etching a high-Fe-content PtPdFe nanoparticle precursor. The final PtPd-x/C having a large amount of PtPd exposed on the surface can effectively increase the utilization efficiency of the mass-based unit precious-metal to facilitate glycerol electrooxidation. Attractively, the optimal PtPd-6/C not only exhibits higher electrochemically active surface area (113.33 cm² mg_PtPd⁻¹), oxidation peak current (0.86 A mg_PtPd⁻¹) and stability (0.48 A mg_PtPd⁻¹ after 3000 s and 5.8% current decreases after 400 cycles), but also shows excellent CO tolerance compared to others. This work demonstrates that the design of a multi-component noble metal composite is a feasible way to obtain some efficient electrocatalysts.