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Evolutionary identification of affinity peptides for the detection of sepsis biomarker procalcitonin†
J. P. Park,C. Y. Park,A. Y. Park,M. Y. Ryu
RSC Advances Pub Date : 10/16/2015 00:00:00 , DOI:10.1039/C5RA20260D
Abstract

We demonstrate for the first time the use of phage display for identification and selection of novel peptides that are capable of binding to procalcitonin. The best peptide specific for procalcitonin has an amino acid sequence of ‘MSCAGHMCTRFV’ and the binding affinity was observed with a nanomolar binding.

Graphical abstract: Evolutionary identification of affinity peptides for the detection of sepsis biomarker procalcitonin
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