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Friedel–Crafts alkylation of heteroarenes and arenes with indolyl alcohols for construction of 3,3-disubstituted oxindoles†
Xiaoxiao Wang,Jian Liu,Lubin Xu,Zhihui Hao,Liang Wang,Jian Xiao
RSC Advances Pub Date : 11/20/2015 00:00:00 , DOI:10.1039/C5RA21919A
Abstract

An intriguing camphorsulfonic acid catalyzed Friedel–Crafts alkylation of heteroarenes and arenes with indolyl alcohols has been developed featuring mild reaction conditions, wide substrate scope and high yields. This reaction provides an efficient method to access biologically important heterocyclic oxindole derivatives.

Graphical abstract: Friedel–Crafts alkylation of heteroarenes and arenes with indolyl alcohols for construction of 3,3-disubstituted oxindoles
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