Enantiopure arene dioxides: chemoenzymatic synthesis
and application in the production of trans-3,4-dihydrodiols
Derek R. Boyd,Narain D. Sharma,Colin R. O’Dowd,Francis Hempenstall
Chemical Communications Pub Date : 10/19/2000 00:00:00 , DOI:10.1039/B006837N
Abstract
Enantiopure syn- and anti-arene dioxides are synthesised from cis-dihydrodiol metabolites; anti-benzene dioxides are reduced to enantiopure trans-3,4-dihydrodiols while syn-benzene dioxides racemise thermally via 1,4-dioxocins.
