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Enantiopure oxazolidinones as chiral acids in the asymmetric protonation of N-Boc pyrrole derived enolates
David R. Carbery,Timothy J. Donohoe
Chemical Communications Pub Date : 02/16/2004 00:00:00 , DOI:10.1039/B316719D
Abstract

The first use of geminally disubstituted oxazolidinones as chiral protonating agents is described: these new acids are able to directly protonate an enolate generated by the ammonia free partial reduction of an electron deficient pyrrole and give up to 68% ee in the pyrroline product.

Graphical abstract: Enantiopure oxazolidinones as chiral acids in the asymmetric protonation of N-Boc pyrrole derived enolates
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