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Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols†
Charles C. J. Loh,Fangfang Pan,Dieter Enders
Chemical Communications Pub Date : 08/22/2012 00:00:00 , DOI:10.1039/C2CC35644A
Abstract

The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition–hemiaminalization sequence using the Jørgensen–Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion.

Graphical abstract: Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2-ols
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