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Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity†
Minoru Ueda,Gangqiang Yang,Yuuki Nukadzuka,Yasuhiro Ishimaru,Satoru Tamura,Yoshiyuki Manabe
Organic & Biomolecular Chemistry Pub Date : 10/15/2014 00:00:00 , DOI:10.1039/C4OB02106A
Abstract

12-O-β-D-Glucopyranosyljasmonic acid (JAG, 1) induces nyctinastic leaf-folding of Samanea saman. The SAR studies of 1 revealed the unique role of its glycone moiety. Biological activity and the target affinity of 1 were affected by the stereochemistry of the glycone moiety. JAG belongs to a unique class of ligands in which the structure of the glycone moiety is involved in the molecular recognition by the target protein.

Graphical abstract: Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity
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