Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles†
Aaroa P. Salas,Alfredo F. Braña,Martina Palomino,Antonio Pineda-Lucena,Rodrigo J. Carbajo,Carmen Méndez,Francisco Moris,José A. Salas
Chemical Communications Pub Date : 05/27/2009 00:00:00 , DOI:10.1039/B905068J
Abstract
We report the generation of novel glycosylated indolocarbazoles by combinatorial biosynthesis, and the identification of two novel potent and selective compounds inhibitors of JAK2 and Ikkb kinases.
