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FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells†
Anming Tang,Bin Mei,Weijuan Wang,Wanglai Hu,Fang Li,Jun Zhou,Qing Yang,Hua Cui,Mian Wu,Gaolin Liang
Nanoscale Pub Date : 08/01/2013 00:00:00 , DOI:10.1039/C3NR03339B
Abstract

By employing fluorescence resonance energy transfer (FRET) quenching, we rationally designed two new FITC–quencher based nanoprobes for effectively sensing caspase 3 (Casp3) in vitro and in cells. Our nanoprobes hold promise for assessing the chemotherapeutic effect of cancer treatment.

Graphical abstract: FITC–quencher based caspase 3-activatable nanoprobes for effectively sensing caspase 3 in vitro and in cells
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