Ag nanoparticles were firstly encapsulated into graphene oxide (GO) scrolls to form GO–Ag scrolls by a molecular combing method. Horizontally and perpendicularly aligned GO–Ag scrolls were then crossly stacked by a dry transfer method to form GO–Ag scroll meshes. After being reduced by hydrazine, the device based on reduced GO–Ag (rGO–Ag) scroll meshes shows 3 orders of magnitude higher response in humidity sensing compared to that of reduced GO (rGO) scroll meshes. In addition, rGO–Ag scroll meshes-based device shows good humidity sensing stability in ambient conditions over a month.