Formation of bicyclic pyrroles from the catalytic coupling reaction of 2,5-disubstituted pyrroles with terminal alkynes, involving the activation of multiple C–H bonds†
Chae S. Yi,Jie Zhang
Chemical Communications Pub Date : 04/21/2008 00:00:00 , DOI:10.1039/B804263B
Abstract

Substituted bicyclic pyrroles are produced directly from the coupling reaction of 2,5-disubstituted pyrroles with terminal alkynes, involving the activation of multiple C–H bonds and regioselective cyclisation.

Graphical abstract: Formation of bicyclic pyrroles from the catalytic coupling reaction of 2,5-disubstituted pyrroles with terminal alkynes, involving the activation of multiple C–H bonds