Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework†,10.1039/C8CC03447H

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Highly enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework†

Koichi Tanaka,Kenji Sakuragi,Hiroto Ozaki,Yoshiki Takada

Chemical Communications Pub Date : 05/25/2018 00:00:00 , DOI:10.1039/C8CC03447H

Abstract

The first enantioselective Friedel–Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal–organic framework constructed from (R)-2,2′-dihydroxy-1,1′-binaphthyl-6,6′-dicarboxylic acid has been developed. The reaction proceeded in high yields (∼96%) with excellent enantioselectivities (∼98% ee).