Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones†,10.1039/C4RA08631G

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Highly efficient synthesis and antioxidant capacity of N-substituted benzisoselenazol-3(2H)-ones†

Agata J. Pacuła,Jacek Ścianowski,Krzysztof B. Aleksandrzak

RSC Advances Pub Date : 09/29/2014 00:00:00 , DOI:10.1039/C4RA08631G

Abstract

A new, general one step synthesis of N-substituted benzisoselenazol-3(2H)-ones based on the reaction of o-iodobenzamides with lithium diselenide, is described. A series of alkyl and aryl derivatives was obtained in high yields (up to 98%). Their GPx-like antioxidant activity, tested by NMR, showed a significantly higher activity than ebselen.