Highly regioselective Lewis acid-catalyzed [3+2] cycloaddition of alkynes with donor–acceptor oxiranes by selective carbon–carbon bond cleavage of epoxides†
Renrong Liu,Mei Zhang
Chemical Communications Pub Date : 11/09/2011 00:00:00 , DOI:10.1039/C1CC15669A
Abstract
A novel, efficient, highly regioselective Sc(OTf)3-catalyzed [3+2] cycloaddition of electron-rich alkynes with donor–acceptor oxiranes via highly chemoselective C–C bond cleavage under mild conditions was developed.
![Graphical abstract: Highly regioselective Lewis acid-catalyzed [3+2] cycloaddition of alkynes with donor–acceptor oxiranes by selective carbon–carbon bond cleavage of epoxides](http://hg.y866.cn/compound/lib/scimg/usr/1/C1CC15669A.jpg)
