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Facile synthesis of 2-substituted quinolines and 3-alkynyl-2-aryl-2H-Indazole via SnCl2-mediated reductive cyclization†
Narayanasamy Sudhapriya,Avanashiappan Nandakumar,Paramasivan Thirumalai Perumal
RSC Advances Pub Date : 10/29/2014 00:00:00 , DOI:10.1039/C4RA09153A
Abstract

A rapid and efficient SnCl2·2H2O mediated synthesis of quinolines and indazoles has been developed using A3-coupling followed by reductive cyclization. The key highlights are the formation of quinoline in a one-pot fashion and indazole through N–N bond formation.

Graphical abstract: Facile synthesis of 2-substituted quinolines and 3-alkynyl-2-aryl-2H-Indazole via SnCl2-mediated reductive cyclization
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