Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction†
Arun K. Ghosh,Jorden Kass
Chemical Communications Pub Date : 01/25/2010 00:00:00 , DOI:10.1039/B924807B
Abstract
We have developed a practical synthesis of unique nucleoside derivatives viaTiCl4 promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation.
