Highly regioselective synthesis of 4-tosylthiomorpholine via intramolecular cyclization of N-tethered thioalkenols†,10.1039/C6OB01869F

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Highly regioselective synthesis of 4-tosylthiomorpholine via intramolecular cyclization of N-tethered thioalkenols†

Anil K. Saikia,Manash J. Deka,Upasana Borthakur

Organic & Biomolecular Chemistry Pub Date : 10/13/2016 00:00:00 , DOI:10.1039/C6OB01869F

Abstract

A one-pot, metal-free procedure has been developed for the synthesis of 4-tosylthiomorpholine from N-tethered thioalkenols via bromination, cyclization and subsequent elimination reaction in good yields. The reaction is found to be highly regioselective.