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Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles†
Christopher L. Paradise,Pooja R. Sarkar,Mina Razzak,Jef K. De Brabander
Organic & Biomolecular Chemistry Pub Date : 04/04/2011 00:00:00 , DOI:10.1039/C1OB05390F
Abstract

Amino acid-derived propargylic amides are cyclised in a one-pot, Au(III)-catalysed operation to yield 5-bromomethyl oxazoles. These compounds are further elaborated to bis-heterocycles, dipeptide mimics and more.

Graphical abstract: Gold-catalysed synthesis of amino acid-derived 2,5-disubstituted oxazoles
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