Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor†
Bhagavathy Shanmugasundaram,Aleksandra W. Debowski,Rebecca J. Dennis,Gideon J. Davies,David J. Vocadlo,Andrea Vasella
Chemical Communications Pub Date : 09/29/2006 00:00:00 , DOI:10.1039/B612154C
Abstract
Synthesis of a PUGNAc–imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.
