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Hydroxy-assisted regio- and stereoselective synthesis of functionalized alkenes via phosphine-catalyzed β′-umpolung addition of o-hydroxy aromatic aldimines to allenoates†
Kunpeng Cheng,Yishu Bao,Jiahua Wang,Zonghao Dai,Jinrong Lu,Qingfa Zhou
Organic Chemistry Frontiers Pub Date : 06/28/2018 00:00:00 , DOI:10.1039/C8QO00460A
Abstract

An unprecedented β′-umpolung addition of o-hydroxy aromatic aldimines with allenoates has been developed under the catalysis of phosphine. The reaction provides an efficient approach to the synthesis of functionalized alkenes in moderate to good yields with high stereoselectivities under mild conditions. The asymmetric version of this β′-umpolung addition has also been studied using chiral phosphines.

Graphical abstract: Hydroxy-assisted regio- and stereoselective synthesis of functionalized alkenes via phosphine-catalyzed β′-umpolung addition of o-hydroxy aromatic aldimines to allenoates
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