Identification of broad specificity P450CAM variants by primary screening against indole as substrate
Ayhan Çelik,Robert E. Speight,Nicholas J. Turner
Chemical Communications Pub Date : 07/05/2005 00:00:00 , DOI:10.1039/B506156C
Abstract
High-throughput screening of cytochrome P450CAM libraries, for their ability to oxidise indole to indigo and indirubin, has resulted in the identification of variants with activity towards the structurally unrelated substrate diphenylmethane.
