A noncovalent hybrid of [Pd(phen)(OAc)2] and st-DNA for the enantioselective hydroamination of β-nitrostyrene with methoxyamine†‡,10.1039/D1OB00714A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A noncovalent hybrid of [Pd(phen)(OAc)2] and st-DNA for the enantioselective hydroamination of β-nitrostyrene with methoxyamine†‡

Mrityunjoy Pal,Dulal Musib,Maynak Pal,Gopal Rana,Gobinda Bag,Subrata Dutta,Mithun Roy

Organic & Biomolecular Chemistry Pub Date : 05/13/2021 00:00:00 , DOI:10.1039/D1OB00714A

Abstract

We developed a novel Pd-catalysed enantioselective synthesis of C–N bonds using the chiral scaffold of DNA. The non-covalently linked [Pd(phen)(OAc)₂] with st-DNA catalysed the Markonicov hydroamination of β-nitrostyrene with methoxyamine for the first time with >75% enantiomeric excess (ee) in an aqueous buffer (pH 7.4) at room temperature.