Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs†
Cynthia Demicheli,Frédéric Frézard,John B. Mangrum,Nicholas P. Farrell
Chemical Communications Pub Date : 08/26/2008 00:00:00 , DOI:10.1039/B809186B
Abstract
SbIII competes with ZnII for its binding to the CCHC zinc finger domain of the NCp7 protein of HIV-1, indicating that zinc finger proteins may be targets for antimony-based drugs and thus responsible for their important pharmacological actions.
