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Gold(i)-catalyzed intramolecular hydroamination and ring-opening of sulfonamide-substituted 2-(arylmethylene)cyclopropylcarbinols†
Di-Han Zhang,Kang Du,Min Shi
Organic & Biomolecular Chemistry Pub Date : 04/03/2012 00:00:00 , DOI:10.1039/C2OB25512J
Abstract

An interesting gold(I)-catalyzed intramolecular hydroamination and ring-opening of sulfonamide-substituted 2-(arylmethylene)cyclopropylcarbinols has been described in this context. A variety of 4-substituted isoxazolidine derivatives were obtained in good to high yields through a highly regioselective cleavage of a carbon–carbon single bond in the cyclopropane.

Graphical abstract: Gold(i)-catalyzed intramolecular hydroamination and ring-opening of sulfonamide-substituted 2-(arylmethylene)cyclopropylcarbinols
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