Kinetic resolution of 2-substituted-2,3-dihydrofurans by a palladium-catalyzed asymmetric Heck reaction†,10.1039/C5RA17374D

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Kinetic resolution of 2-substituted-2,3-dihydrofurans by a palladium-catalyzed asymmetric Heck reaction†

Shi-Li Wan,Chang-Hua Ding,Bin Xu,Xue-Long Hou

RSC Advances Pub Date : 08/28/2015 00:00:00 , DOI:10.1039/C5RA17374D

Abstract

The kinetic resolution of 2-substituted-dihydrofurans via a palladium-catalyzed asymmetric Heck reaction was realized, providing optically active 2-substituted-dihydrofurans and trans-2,5-disubstituted-dihydrofurans in high yield and good enantioselectivities with an S factor up to 70.