A single step, mild, environmentally friendly green method has been developed for the synthesis of physiologically active 3,4-dihydropyrimidin-2-(1H)-ones employing L-tyrosine as catalyst under solvent-free conditions at room temperature via grinding. The procedure is efficient, time saving and gives high-yields. The structures and purity of these compounds were confirmed by FT-IR, NMR (¹H and ¹³C) and HRMS spectral analysis. DFT calculations have been used to show the effectiveness of L-tyrosine as a suitable catalyst for the above reaction.