A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite†
Tongqiang Wang,Yuanyuan Hu,Songlin Zhang
Organic & Biomolecular Chemistry Pub Date : 04/07/2010 00:00:00 , DOI:10.1039/C001931C
Abstract

The widely available carbonyl compounds react with Grignard reagents in the presence of diethyl phosphite to give the corresponding olefins in good to excellent yields: A range of conjugated dienes, terminal olefins, multisubstituted-alkenes and conjugated enynes could be readily obtained by the method in mild conditions.

Graphical abstract: A novel and efficient method for the olefination of carbonyl compounds with Grignard reagents in the presence of diethyl phosphite