Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation†,10.1039/C9CC01265F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation†

Mehdi Amoura,Françoise Illien,Alain Joliot,Karine Guitot,John Offer,Sandrine Sagan,Fabienne Burlina

Chemical Communications Pub Date : 04/01/2019 00:00:00 , DOI:10.1039/C9CC01265F

Abstract

A series of cyclic lipidated oligo-Arg cell penetrating peptides were synthesised with varied macrocycle size and lipid chain anchoring site. The study of their cellular uptake revealed different structural requirements to promote efficient glycosaminoglycan-dependent endocytosis and direct translocation.