Heterogeneous asymmetric hydrogenation of CO and CC bonds over chiral molecule-modified metal particles represents an important route for the production of chiral compounds. In this mini review, we first briefly introduced the background of heterogeneous asymmetric hydrogenation and the remaining challenges in this field. Then, we highlighted recent important progress in the understanding of the reaction mechanism in terms of the acid–base properties of supports and the effects of the size/shape of metal particles. Finally, we summarized the possible models proposed for the substrate–modifier adsorption and their interaction in asymmetric hydrogenation reactions.