Lipase-catalysed direct Mannich reaction in water: utilization of biocatalytic promiscuity for C–C bond formation in a “one-pot” synthesis†
Kun Li,Ting He,Chao Li,Xing-Wen Feng,Na Wang,Xiao-Qi Yu
Green Chemistry Pub Date : 03/26/2009 00:00:00 , DOI:10.1039/B817524A
Abstract
A novel lipase-catalysed direct Mannich reaction has been developed under aqueous conditions in a “one-pot” strategy. Interestingly, these promiscuous reactions can be greatly promoted by water and generally require aromatic aldehydes.
