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Lewis acid-catalysed one pot synthesis of substituted xanthenes†
Esther Böβ,Tim Hillringhaus,Jacqueline Nitsch,Martin Klussmann
Organic & Biomolecular Chemistry Pub Date : 12/15/2010 00:00:00 , DOI:10.1039/C0OB00954G
Abstract

A direct synthesis of substituted xanthenes from salicylaldehydes and cyclohexenones or tetralones has been developed. The reaction is catalysed by Lewis acids like scandium triflate and furnishes substituted xanthenes in good to excellent yields using either microwave or thermal heating. Microwave heating results in significantly shortened reaction times of 30 min and generally higher yields.

Graphical abstract: Lewis acid-catalysed one pot synthesis of substituted xanthenes
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